主题:RW-SPM: RegionWise Statistical Parametric Mapping
主讲人:潘文亮 中国科学院
主持人:姜云卢 暨南大学
时间:2025年11月25日(周二)上午10:30-11:30
地点:暨南大学石牌校区经济学院大楼(中惠楼)323室
摘要
Statistical Parametric Mapping (SPM) is central to neuroimaging analysis, detecting associations between brain regions and clinical or genetic predictors. Yet anatomical variability, signal‐pattern heterogeneity, imperfect warping, and acquisition artifacts introduce misalignment errors that undermine accuracy and statistical power. To address these challenges, we propose Regionwise SPM (RW-SPM)—a novel framework that combines region‐based aggregation with adaptive smoothing guided by anatomical landmarks. By partitioning images into small, coherent regions and embedding their aggregated voxel distributions into a Hilbert space, RWSPM enables robust, distribution‐based association testing while remaining computationally efficient. Theoretically and in simulations, RWSPM markedly reduces misalignment bias, controls Type I error rates, and boosts sensitivity. Application to real neuroimaging data confirms its ability to improve both the accuracy and reliability of SPM results.
主讲人简介

潘文亮,现任中国科学院数学与系统科学研究院副研究员及博士生导师,专注于统计学习算法、医学图像数据分析和度量空间的非参数方法等领域研究。在Annals of Statistics、Journal of the American Statistical Association等统计学顶级杂志上发表了20篇以上学术论文,获得2022年教育部高等学校科学研究优秀成果自然科学类二等奖(排名第二)。主持的科研项目涵盖国家自然科学基金委青年基金B类、面上项目等。同时,担任北京生物医学统计与数据管理研究会副理事长,以及中国现场统计研究会统计交叉科学研究分会副秘书长。
欢迎感兴趣的师生参加!
校对|姜云卢
责编| 彭毅
初审| 姜云卢
终审发布| 何凌云
(来源:暨南大学经济学院微信公众号)

